Antifungal, antioxidant and cytotoxic activities of chitosan nanoparticles and its use as an edible coating on vegetables.
Identifieur interne : 000850 ( Main/Exploration ); précédent : 000849; suivant : 000851Antifungal, antioxidant and cytotoxic activities of chitosan nanoparticles and its use as an edible coating on vegetables.
Auteurs : K. Divya [Inde] ; Vijayan Smitha [Inde] ; M S Jisha [Inde]Source :
- International journal of biological macromolecules [ 1879-0003 ] ; 2018.
Descripteurs français
- KwdFr :
- Additifs alimentaires (composition chimique), Additifs alimentaires (pharmacologie), Animaux (MeSH), Antifongiques (composition chimique), Antifongiques (pharmacologie), Antioxydants (composition chimique), Antioxydants (pharmacologie), Champignons (croissance et développement), Chitosane (composition chimique), Chitosane (pharmacologie), Cytotoxines (composition chimique), Cytotoxines (pharmacologie), Lignée cellulaire (MeSH), Légumes (MeSH), Nanoparticules (composition chimique), Souris (MeSH).
- MESH :
- composition chimique : Additifs alimentaires, Antifongiques, Antioxydants, Chitosane, Cytotoxines, Nanoparticules.
- croissance et développement : Champignons.
- pharmacologie : Additifs alimentaires, Antifongiques, Antioxydants, Chitosane, Cytotoxines.
- Animaux, Lignée cellulaire, Légumes, Souris.
English descriptors
- KwdEn :
- Animals (MeSH), Antifungal Agents (chemistry), Antifungal Agents (pharmacology), Antioxidants (chemistry), Antioxidants (pharmacology), Cell Line (MeSH), Chitosan (chemistry), Chitosan (pharmacology), Cytotoxins (chemistry), Cytotoxins (pharmacology), Food Additives (chemistry), Food Additives (pharmacology), Fungi (growth & development), Mice (MeSH), Nanoparticles (chemistry), Vegetables (MeSH).
- MESH :
- chemical , chemistry : Antifungal Agents, Antioxidants, Chitosan, Cytotoxins, Food Additives.
- chemical , pharmacology : Antifungal Agents, Antioxidants, Chitosan, Cytotoxins, Food Additives.
- chemistry : Nanoparticles.
- growth & development : Fungi.
- Animals, Cell Line, Mice, Vegetables.
Abstract
Chitosan is an abundant non-toxic, biodegradable polymer with versatile applications. It is a linear amino polysaccharide obtained from crustacean shells. The chitosan nanoparticles (ChNP) prepared by ionic gelation of chitosan has greater activity owing to its small size. ChNP has been proved to be effective in controlling plants diseases. In this work, we have endeavoured to study the antifungal and antioxidant activity of ChNP and use of ChNP as a vegetable coating material. The activity of ChNP against selected plant pathogens Rhizoctonia solani, Fusarium oxysporum, Collectotrichum acutatum, and Phytophthora infestans were studied along with a brief account of its mechanism of action. The antioxidant activity of ChNP was also analysed. The ability of ChNP as a coating material to improve the shelf life of tomato, chilly and brinjal was also studied. The cytotoxicity effect of ChNP against L929 fibroblast cells was studied. ChNP had good antifungal activity against all selected pathogens compared to Amphotericin B. Significant antioxidant activity was obtained. The vegetables coated with different concentrations of ChNP (1%, 2%, 3%, 4% and 5%) showed decreased weight loss compared to uncoated control. ChNP was shown to have decreased cytotoxicity thus making it an ideal antifungal, antioxidant and coating agent.
DOI: 10.1016/j.ijbiomac.2018.03.130
PubMed: 29578005
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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It is a linear amino polysaccharide obtained from crustacean shells. The chitosan nanoparticles (ChNP) prepared by ionic gelation of chitosan has greater activity owing to its small size. ChNP has been proved to be effective in controlling plants diseases. In this work, we have endeavoured to study the antifungal and antioxidant activity of ChNP and use of ChNP as a vegetable coating material. The activity of ChNP against selected plant pathogens Rhizoctonia solani, Fusarium oxysporum, Collectotrichum acutatum, and Phytophthora infestans were studied along with a brief account of its mechanism of action. The antioxidant activity of ChNP was also analysed. The ability of ChNP as a coating material to improve the shelf life of tomato, chilly and brinjal was also studied. The cytotoxicity effect of ChNP against L929 fibroblast cells was studied. ChNP had good antifungal activity against all selected pathogens compared to Amphotericin B. Significant antioxidant activity was obtained. The vegetables coated with different concentrations of ChNP (1%, 2%, 3%, 4% and 5%) showed decreased weight loss compared to uncoated control. 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It is a linear amino polysaccharide obtained from crustacean shells. The chitosan nanoparticles (ChNP) prepared by ionic gelation of chitosan has greater activity owing to its small size. ChNP has been proved to be effective in controlling plants diseases. In this work, we have endeavoured to study the antifungal and antioxidant activity of ChNP and use of ChNP as a vegetable coating material. The activity of ChNP against selected plant pathogens Rhizoctonia solani, Fusarium oxysporum, Collectotrichum acutatum, and Phytophthora infestans were studied along with a brief account of its mechanism of action. The antioxidant activity of ChNP was also analysed. The ability of ChNP as a coating material to improve the shelf life of tomato, chilly and brinjal was also studied. The cytotoxicity effect of ChNP against L929 fibroblast cells was studied. ChNP had good antifungal activity against all selected pathogens compared to Amphotericin B. Significant antioxidant activity was obtained. The vegetables coated with different concentrations of ChNP (1%, 2%, 3%, 4% and 5%) showed decreased weight loss compared to uncoated control. ChNP was shown to have decreased cytotoxicity thus making it an ideal antifungal, antioxidant and coating agent.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Divya</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smitha</LastName><ForeName>Vijayan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jisha</LastName><ForeName>M S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India. Electronic address: jishams@mgu.ac.in.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Biol Macromol</MedlineTA><NlmUniqueID>7909578</NlmUniqueID><ISSNLinking>0141-8130</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003603">Cytotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005503">Food Additives</NameOfSubstance></Chemical><Chemical><RegistryNumber>9012-76-4</RegistryNumber><NameOfSubstance UI="D048271">Chitosan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048271" MajorTopicYN="N">Chitosan</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003603" MajorTopicYN="N">Cytotoxins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005503" MajorTopicYN="N">Food Additives</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014675" MajorTopicYN="Y">Vegetables</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antifungal activity</Keyword><Keyword MajorTopicYN="N">Antioxidant activity</Keyword><Keyword MajorTopicYN="N">Chitosan</Keyword><Keyword MajorTopicYN="N">Coating agent</Keyword><Keyword MajorTopicYN="N">Cytotoxicity</Keyword><Keyword MajorTopicYN="N">Nanoparticles</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>02</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29578005</ArticleId><ArticleId IdType="pii">S0141-8130(17)32287-0</ArticleId><ArticleId IdType="doi">10.1016/j.ijbiomac.2018.03.130</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Divya, K" sort="Divya, K" uniqKey="Divya K" first="K" last="Divya">K. Divya</name></noRegion><name sortKey="Jisha, M S" sort="Jisha, M S" uniqKey="Jisha M" first="M S" last="Jisha">M S Jisha</name><name sortKey="Smitha, Vijayan" sort="Smitha, Vijayan" uniqKey="Smitha V" first="Vijayan" last="Smitha">Vijayan Smitha</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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